Methamphetamine regulates βAPP processing in human neuroblastoma cells.

摘要: Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in human brain, ultimately leading neurocognitive disorders. Strikingly, brain changes, tissue damage neuropsychological symptoms due Meth exposure compels necessitates link probability of risk developing premature Alzheimer's disease, progressive neurodegenerative disorder characterized by amyloid plaques composed amyloid-β peptides clinical dementia. These are derived from sequential cleavages β-amyloid precursor protein β- γ-secretases. Previous studies reveals evidence for both positive negative pertaining cognitive functioning based on dosage paradigm duration revealing beneficial psychotropic profile under some conditions deleterious deficits others. In this context, we proposed examine effect βAPP metabolism βAPP-cleaving secretases neuroblastoma SH-SY5Y cell line. Our results showed that dose-dependently increases BACE1 expression catalytic activity, while its α-cleavage activity main α-secretase ADAM10 display bell-curve shape. To our knowledge, present study first demonstrate can control secretases. Moreover, propose these findings decline might an outcome high whereas acute short-term drug use which stimulated sAPPα produce improvements cognition disorders such as AD.