Invasive micropapillary urothelial carcinoma of the bladder.

摘要: In this report, we present the clinicopathologic features of 13 cases invasive micropapillary variant urothelial carcinoma. This is a rare and aggressive bladder cancer recognized by current World Health Organization classification urologic tumors. The component varied from 50% to 100% tumor specimen; in 10 cases, composed greater than 70% tumor, with 5 showing pure architectural pattern solid expansile nests slender papillae within tissue retraction spaces pseudoglandular growth prominent ring-like structures (2 15%) carcinoma squamous differentiation 15%); streaking was additionally 2 (15%). At histology, individual cells had abundant eosinophilic cytoplasm nuclei nucleoli irregular distribution chromatin, frequent mitotic figures. Most neoplastic low intermediate nuclear grade occasional pleomorphism. Eight mixed concurrent conventional high-grade or glandular 3 1 case(s), respectively. All patients advanced-stage (>pT2), 8 (62%) lymph node metastasis. Immunohistochemical staining demonstrated that both associated carcinomas were positive for MUC1 2, cytokeratin 7, PTEN, p53, Ki-67. Her2Neu, uroplakin, 20, 34betaE12, CA125, p16 4, 10, 8, 3, MUC5A, MUC6, CDX2 negative all cases. Follow-up information available (range, 2-21 months; mean, months). Eleven died disease 14 months, alive at 21 months. Univariate statistical analysis showed survival differences between (P < .0001). summary, an poor prognosis presents advanced clinical stage. immunophenotype supports origin; immunoreactivity Her2Neu PTEN might be relevant terms future targeting therapy. morphologic diversity may represent diagnostic pitfall limited samples, where its distinction critical management.