Melanoma: Molecular Classification and Therapy

摘要: Since the original classification and detailed histomorphological description of cutaneous melanoma, no major advancement has been made in treatment advance stages this lethal disease. This chapter offers a brief review classic melanoma subtypes as described by Dr. Wallace Clark correlation with emerging types. Emphasis is given on molecular types based driver mutations found many different groups. The most important are alterations pathways involved cellular proliferation, ultimately leading to tumor survival, growth, metastases. These include point BRAF, NRAS, GNAQ/GNA11, well KIT. Capitalizing discovery these findings, prominent clinicians researchers, collaboration pharmaceutical industry, set up rapidly develop drugs that specific inhibitors effects mutations. BRAF inhibitors, MEK Kit inhibitors. new therapies highlighting fact that, although prolonging patient they fail control spread However combination therapy between kinase immunotherapy encouraging results ought be further studied developed.