Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy.

摘要: Human plasminogen-derived angiostatin is one of the most potent antiangiogenic agents currently known. However, it unclear whether also effective against accelerated tumor growth induced by local up-regulation factors, including angiogenesis stimulators, such as in regenerating liver. Prior to addressing this question, we tested, mice, continuous administration could improve its biological effects. This assumption was based on relatively short half-life well theoretical necessity suppress tumor-induced continually. The findings presented here clearly indicate be superior conventional twice-daily bolus injections. Using maximally regimen 100 mg/kg/day via s.c. pump infusion, found not only primary tumors but significantly inhibit outgrowth colorectal hepatic metastases resting liver and even after 70% partial hepatectomy. In conclusion, play an important role patients subjected hepatectomy prevent residual micrometastases, provided administered continuously obtain maximal