Subclinical Rejection Associated with Chronic Allograft Nephropathy in Protocol Biopsies as a Risk Factor for Late Graft Loss
作者： F. Moreso , M. Ibernon , M. Gomà , M. Carrera , X. Fulladosa
DOI: 10.1111/J.1600-6143.2005.01230.X
关键词:
摘要: Chronic allograft nephropathy (CAN) in protocol biopsies is associated with graft loss while the association between subclinical rejection (SCR) and outcome has yielded contradictory results. We analyze predictive value of SCR and/or CAN on death-censored survival. Since 1988, a biopsy was done during first 6 months stable grafts serum creatinine <300 micromol/L proteinuria <1 g/day. Biopsies were evaluated according to Banff criteria. Borderline changes acute grouped as SCR. defined presence interstitial fibrosis tubular atrophy. Mean follow-up 91 +/- 46 months. Sufficient tissue obtained 435 transplants. classified normal (n = 186), 74), 110) 65). Presence old donors, percentage panel reactive antibodies before biopsy. Cox regression analysis showed that (relative risk [RR]: 1.86, 95% confidence interval [CI]: 1.11-3.12; p 0.02) hepatitis C virus (RR: 2.27, CI: 1.38-3.75; 0.01) independent predictors In biopsies, detrimental effect fibrosis/tubular atrophy long-term survival modulated by
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