Muscle and plasma amino acids following injury. Influence of intercurrent infection.

摘要: The present study was undertaken to determine intracellular amino acid patterns in patients with multiple trauma, whether or not complicated by sepsis and during convalescence. A percutaneous muscle biopsy performed three four days following major accidental injury ten analyzed for free acids. Venous blood drawn at the time of plasma Five developed a repeat on 8 11. In five late convalescent period (anabolic phase). marked depletion nonessential acids occurred both due decrease (50%) glutamine, which equally states. essential increased injury. During sepsis, further increase observed return toward normal period. injury, most rise branched-chain acids, phenylalanine, tryosine methionine. With phenylalanine occurred, while levels remain unchanged. convalescence, arginine, histidine were below normal, whereas methionine elevated. pattern after trauma essentially same as earlier described elective operation. This suggests common response irrespective degree may indicate that pump settings regulate transport follow "all none" rule. high suggest energy deficit this state is an impairment substrate use rather than availability. concentrations aromatic be altered liver function. phase) low certain key inadequate nutrition. difficulties nourishing injured septic patient are well recognized. these catabolic states important application optimal, aggressive nutritional regimen.