Micro RNAs: an arguable appraisal in medicine.

摘要: Micro RNAs (miRNAs) represent a newly discovered class of regulatory molecules in the human body. miRNA is short double stranded RNA sequence interfering with mRNA, causing most cases, inhibition translation. Synthesis miRNAs shows an increasing developmental pattern and postnatally are synthesized all cells possessing transcriptional machinery. usually target several mRNAs therefore conclusive evidences proving their functions not always ease to be acquired. In spite this difficulty, were firmly established development, cardiovascular neural diseases, cancer. Many have been reported associated physiological state and/or tissues. This finding becomes fundamental, especially when consider that these can released from cell into intracellular space or circulation. Correlation between production tissues its contribution multisource pool circulation focus biomarker-oriented researchers. Recently, circulating suggested applicable as biomarkers types cancer, injury, diabetes. Role organism intercellular signaling still under broad investigation. Several mimics, intended for treatment disease, being currently tested clinical trials.