Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study.

摘要: BACKGROUND The etiology of dementia may partly be underpinned by impaired lung function via systemic inflammation and hypoxia. OBJECTIVE To prospectively examine the association between chronic obstructive pulmonary disease (COPD) subclinical impairments in risk dementia. METHODS In Rotterdam Study, we assessed incident participants with Preserved Ratio Impaired Spirometry (PRISm; FEV1/FVC≥0.7, FEV1 <  80%) COPD (FEV1/FVC <  0.7) compared to those normal spirometry (controls; FEV1≥80%). Hazard ratios (HRs) 95%confidence intervals (CI) for were adjusted age, sex, education attainment, smoking status, systolic blood pressure, body mass index, triglycerides, comorbidities Apolipoprotein E (APOE) genotype. RESULTS Of 4,765 participants, 110 (2.3%) developed after 3.3 years. Compared controls, PRISm, but not COPD, had an increased all-type (adjusted HRPRISm 2.70; 95%CI, 1.53-4.75; HRCOPD 1.03; 0.61-1.74). These findings primarily driven men smokers. Similarly, FVC%predicted values lowest quartile highest at HR 2.28; 1.31-3.98), as well Alzheimer's (AD; 2.13; 1.13-4.02). CONCLUSION Participants PRISm or a low dementia, higher FVC%predicted, respectively. Further research is needed elucidate whether this causal how might contribute pathogenesis.