Comparative pathology of benign prostatic hyperplasia and prostate cancer.

摘要: Basic studies on the pathogenesis of prostate disease including hypertrophy and cancer have been difficult due to lack suitable animal models. Much effort has directed development appropriate models, yet many obstacles still remain. Rodents do not develop spontaneous prostate, in fact atrophies with advancing age. Guinea pigs appear be a good model study effect hormones gland. Microinvasive prostatic adenocarcinoma occurs spontaneously various species rodents, can induced by radiation, chemical carcinogens. The man dog only mammals which suffer naturally from pathological processes gland associated aging. We review currently available models for benign, malignant assess strengths weaknesses each preclinical investigations.