Abnormalities in pulmonary function in infants with high-risk congenital diaphragmatic hernia.
作者： Michal Rygl , Petra Rounova , Jan Sulc , Krystof Slaby , Zbynek Stranak
DOI: 10.5507/BP.2015.040
关键词:
摘要: Aims. The aim of the study was to analyze lung growth and abnormality infant pulmonary function tests (IPFT) in congenital diaphragmatic hernia (CDH) survivors younger than three years age with respect unfavorable prognostic factors. Methods. Thirty high-risk CDH at 1.32±0.54 years, body weight 9.76±1.25 kg were examined using IPFT: tidal breathing analysis, baby resistance/compliance, whole plethysmography rapid thoracoabdominal compression. Gore-Tex patch used 13% patients (GORE group). Pulmonary hypertension diagnosed managed (iNO Standard protocols appropriate reference values obtained data statistically analysed. Results. High incidence peripheral airway obstruction (70%), increased value functional residual capacity (FRC p ) 191.3±24.5 mL (126.5±36.9 % predicted; P < 0.0005), effective resistance (R eff 1.71±0.93 kPa.L 1 .s (144.4±80.1 0.01) decreased specific compliance respiratory system (C rs /kg) 14.1±2.3 mL.kPa.kg -1 (i.e., 76.1±20.1 predicted, 0.0005) noted infants comparison values. Increased FRC found GORE group (165.7±51.9 versus 120.4±31.2, 0.02) iNO (183.1±52.6 117.8±25.7 mL; 0.0005). Conclusion. A high obstruction, an CDH. Unfavorable factors (Gore-Tex patch, hypertension) correlate more severe alteration infants.
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