Emergence of mutations in the K13 Propeller gene of Plasmodium falciparum isolates from Dakar, Senegal in 2013-2014
作者： Agathe Boussaroque , Bécaye Fall , Marylin Madamet , Cheikhou Camara , Nicolas Benoit
DOI: 10.1128/AAC.01346-15
关键词:
摘要: The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138 Plasmodium falciparum isolates collected 2012 and 2013 from patients residing Dakar, Senegal (M. Torrentino-Madamet et al., Malar J 13:472, 2014, http://dx.doi.org/10.1186/1475-2875-13-472). However, the N554H, Q613H, V637I identified region of K13 92 (5.5%) 2014. There five polymorphisms Plasmodium/Apicomplexa-specific domain (K123R, N137S, N142NN/NNN, T149S, K189T/N).
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