Heterologous and sex differential effects of administering vitamin A supplementation with vaccines: a literature review

摘要: WHO recommends high-dose vitamin A supplementation (VAS) to children from 6 months 5 years of age in low-income countries, order prevent and treat deficiency-associated morbidity mortality. The current policy does not discriminate this recommendation either by sex or vaccination status the child. There is accumulating evidence that effects VAS on morbidity, mortality immunological parameters depend concomitant status. Moreover, these interactions may manifest differently males females. Certain vaccines administered through Expanded Program Immunization have been shown alter all-cause infections other than vaccine-targeted disease. This review summarizes observational studies randomized-controlled trials so-called heterologous non-specific vaccines, with a focus differences. In general, seems enhance particularly for diphtheria-tetanus-pertussis live measles where some studies, although unanimously, show stronger interaction between We suggest should be considered when evaluating early life.