EFFECT OF CHRONIC HYPERCALCEMIA ON THE HEART. AN ANALYSIS OF 18 NECROPSY PATIENTS

摘要: Certain clinical and morphologic cardiac observations are described in 18 necropsy patients, aged 33 to 58 years (mean 45 years) (14 women), with chronic hypercalcemia (11.6 34.4 mg/dl [19.4]) from one nine five years). Primary hyperparathyroidism was present patients secondary the other (of renal origin seven). Cardiac valve anular coronary arterial calcific deposits were 10 (Group I) including four age 51 considerable narrowing of two or three major epicardial arteries. None eight II) had cuspal deposits; only deposits, small each, none significant luminal narrowing. Calcium media ("medial calcinosis"), without intimal deposition, arteries patients. Comparison Group I those II disclosed similar mean ages, durations serum calcium levels, but significantly (p less than 0.05) higher total cholesterol levels (216 versus 163 mg/dl) heart weights (426 320 g). This study demonstrates that is associated accelerated deposition anuli valvular cusps, intima individual myocardial fibers (dystrophic calcification), calcification may be produce narrowing, especially over 200 mg/dl. Thus, viewed as a "risk factor" atherosclerosis.