Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.
作者： Lila S. Nolan , James L. Wynn , Misty Good
DOI: 10.1097/SHK.0000000000001507
关键词:
摘要: Neonatal shock and necrotizing enterocolitis (NEC) are leading causes of morbidity mortality in premature infants. NEC is a life-threatening gastrointestinal illness, the precise etiology which not well understood, but characterized by an immaturity intestinal barrier, altered function adaptive immune system, dysbiosis. The complexities neonatal population necessitate relevant clinical modeling using newborn animals that mimic disease human neonates to better elucidate pathogenesis provide opportunity for discovery potential therapeutics. A wide variety animal species-including rats, mice, piglets, primates-have been used developing experimental models diseases such as shock. This review aims highlight immunologic differences compared with adults assessment advantages drawbacks established both enteral or intraperitoneal induction bacterial pathogens. selection model has benefits unique each type species provides individual opportunities development targeted therapies. discusses physiologic relevance insight they contribute specific diseases:
lww.com 
sci-hub.st 参考文章(102)
Hsueh-wen Chow, Chia-Hua Ho, Does the use of outdoor fitness equipment by older adults qualify as moderate to vigorous physical activity PLOS ONE. ,vol. 13, pp. 1- 13 ,(2018) , 10.1371/JOURNAL.PONE.0196507
Alexandra C. Bolognese, Weng-Lang Yang, Laura W. Hansen, Archna Sharma, Jeffrey M. Nicastro, Gene F. Coppa, Ping Wang, Activation of Invariant Natural Killer T Cells Redirects the Inflammatory Response in Neonatal Sepsis Frontiers in Immunology. ,vol. 9, pp. 833- 833 ,(2018) , 10.3389/FIMMU.2018.00833
Anders Brunse, Päivi Worsøe, Susanne E. Pors, Kerstin Skovgaard, Per T. Sangild, Oral Supplementation With Bovine Colostrum Prevents Septic Shock and Brain Barrier Disruption During Bloodstream Infection in Preterm Newborn Pigs. Shock. ,vol. 51, pp. 337- 347 ,(2019) , 10.1097/SHK.0000000000001131
Kazumichi Fujioka, Flora Kalish, Hui Zhao, Ronald J. Wong, David K. Stevenson, Heme oxygenase-1 deficiency promotes severity of sepsis in a non-surgical preterm mouse model. Pediatric Research. ,vol. 84, pp. 139- 145 ,(2018) , 10.1038/S41390-018-0028-6
Daniel G. Remick, Alfred Ayala, Irshad H. Chaudry, Craig M. Coopersmith, Clifford Deutschman, Judith Hellman, Lyle Moldawer, Marcin F. Osuchowski, Premise for Standardized Sepsis Models. Shock. ,vol. 51, pp. 4- 9 ,(2019) , 10.1097/SHK.0000000000001164
Lee Call, Barbara Stoll, Berthe Oosterloo, Nadim Ajami, Fariha Sheikh, Anja Wittke, Rosaline Waworuntu, Brian Berg, Joseph Petrosino, Oluyinka Olutoye, Douglas Burrin, Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC Microbiome. ,vol. 6, pp. 111- ,(2018) , 10.1186/S40168-018-0498-0
Shreyas K. Roy, Qinghe Meng, Benjamin D. Sadowitz, Michaela Kollisch-Singule, Natesh Yepuri, Joshua Satalin, Louis A. Gatto, Gary F. Nieman, Robert N. Cooney, David Clark, Enteral administration of bacteria fermented formula in newborn piglets: A high fidelity model for necrotizing enterocolitis (NEC). PLOS ONE. ,vol. 13, ,(2018) , 10.1371/JOURNAL.PONE.0201172
Eric Giannoni, Philipp KA Agyeman, Martin Stocker, Klara M Posfay-Barbe, Ulrich Heininger, Ben D Spycher, Sara Bernhard-Stirnemann, Anita Niederer-Loher, Christian R Kahlert, Alex Donas, Antonio Leone, Paul Hasters, Christa Relly, Thomas Riedel, Claudia Kuehni, Christoph Aebi, Christoph Berger, Luregn J Schlapbach, Swiss Pediatric Sepsis Study, None, Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study. The Journal of Pediatrics. ,vol. 201, pp. 30761- 30763 ,(2018) , 10.1016/J.JPEDS.2018.05.048
Madison A. Mara, Misty Good, Joern-Hendrik Weitkamp, Innate and adaptive immunity in necrotizing enterocolitis. Seminars in Fetal & Neonatal Medicine. ,vol. 23, pp. 394- 399 ,(2018) , 10.1016/J.SINY.2018.08.002
Momodou L. Jammeh, Obinna O. Adibe, Elisabeth T. Tracy, Henry E. Rice, Reese H. Clark, P. Brian Smith, Rachel G. Greenberg, Racial/ethnic differences in necrotizing enterocolitis incidence and outcomes in premature very low birth weight infants. Journal of Perinatology. ,vol. 38, pp. 1386- 1390 ,(2018) , 10.1038/S41372-018-0184-X