摘要: A role for the p52 NF-kappaB subunit in tumorigenesis has been steadily emerging since its discovery as a gene associated with chromosomal translocations B- and T-cell lymphomas. Now Eliopoulos co-workers have extended these studies to examine effect of Epstein-Barr virus (EBV)-encoded latent infection membrane protein 1 (LMP1) on p52. They find that LMP1 stimulates processing p100 NF-kappaB. Moreover, nuclear is also expression tumor tissue biopsies. demonstrate pathway leading p100/p52 distinct from engaged by activate other subunits through IkappaBalpha degradation. clearer picture now developing important plays during normal cell growth how subverting function can contribute oncogenesis.