Oncogenes, tumor suppressors and p52 NF-κB

作者: Neil D Perkins

DOI: 10.1038/SJ.ONC.1207139

关键词:

摘要: A role for the p52 NF-kappaB subunit in tumorigenesis has been steadily emerging since its discovery as a gene associated with chromosomal translocations B- and T-cell lymphomas. Now Eliopoulos co-workers have extended these studies to examine effect of Epstein-Barr virus (EBV)-encoded latent infection membrane protein 1 (LMP1) on p52. They find that LMP1 stimulates processing p100 NF-kappaB. Moreover, nuclear is also expression tumor tissue biopsies. demonstrate pathway leading p100/p52 distinct from engaged by activate other subunits through IkappaBalpha degradation. clearer picture now developing important plays during normal cell growth how subverting function can contribute oncogenesis.

参考文章(40)
Patricia C Cogswell, Denis C Guttridge, William K Funkhouser, Albert S Baldwin, Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3 Oncogene. ,vol. 19, pp. 1123- 1131 ,(2000) , 10.1038/SJ.ONC.1203412
P Viatour, M Bentires-Alj, A Chariot, V Deregowski, L de Leval, M-P Merville, V Bours, NF- kappa B2/p100 induces Bcl-2 expression. Leukemia. ,vol. 17, pp. 1349- 1356 ,(2003) , 10.1038/SJ.LEU.2402982
G P Nolan, T Fujita, K Bhatia, C Huppi, H C Liou, M L Scott, D Baltimore, The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Molecular and Cellular Biology. ,vol. 13, pp. 3557- 3566 ,(1993) , 10.1128/MCB.13.6.3557
N D Perkins, A B Agranoff, E Pascal, G J Nabel, An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Molecular and Cellular Biology. ,vol. 14, pp. 6570- 6583 ,(1994) , 10.1128/MCB.14.10.6570
J. Y. Reuther, G. W. Reuther, D. Cortez, A. M. Pendergast, A. S. Baldwin Jr., A requirement for NF-κB activation in Bcr–Abl-mediated transformation Genes & Development. ,vol. 12, pp. 968- 981 ,(1998) , 10.1101/GAD.12.7.968
Yixue Cao, Giuseppina Bonizzi, Tiffany N. Seagroves, Florian R. Greten, Randall Johnson, Emmett V. Schmidt, Michael Karin, IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development Cell. ,vol. 107, pp. 763- 775 ,(2001) , 10.1016/S0092-8674(01)00599-2
Debra Weinstat-Saslow, Maria J. Merino, Richard E. Manrow, Julia A. Lawrence, Ray F. Bluth, Karl D. Wittenbel, Jean F. Simpson, David L. Page, Patricia S. Steeg, Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions Nature Medicine. ,vol. 1, pp. 1257- 1260 ,(1995) , 10.1038/NM1295-1257
Antonino Neri, Chih-Chao Chang, Luigia Lombardi, Mauro Salina, Paolo Corradini, Anna T. Maiolo, R.S.K. Chaganti, Riccardo Dalla-Favera, B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50 Cell. ,vol. 67, pp. 1075- 1087 ,(1991) , 10.1016/0092-8674(91)90285-7