Formation of a new biogenic aldehyde adduct by incubation of tryptamine with rat brain tissue
作者： Rudy Susilo , Henning Damm , Hans Rommelspacher
DOI: 10.1111/J.1471-4159.1988.TB02483.X
关键词:
摘要: Tryptamine was degraded by incubation with rat brain homogenate to an unknown product. The reaction stimulated the nonionic detergents Triton X-100 and Lubrol PX less zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio]1-propanesulfonate (CHAPS). same results were obtained pig bovine brain. monoamine oxidase inhibitor pargyline inhibited strongly, indicating participation of enzyme on reaction. Addition 17,000 g supernatant from increased formation effectively whereas phospholipids or chloroform/methanol (7:3) extract showed only little no effect. Chromatographic electrophoretic properties as well chemical product specific reagents suggest that compound consists indole part amino acid part. could be identified fast atom bombardment mass spectrometry comparison synthetic substance (4R)-2-(3-indolylmethyl)-1,3-thiazolidine-4-carboxylic acid. It is formed enzymatic oxidation tryptamine producing indole-3-acetaldehyde which spontaneously cyclizes free L-cysteine tissue. biogenic aldehydes macromolecules may proceed via analogous
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