Bienzymatic synergism of vanadium oxide nanodots to efficiently eradicate drug-resistant bacteria during wound healing in vivo.

摘要: Antibiotic resistance is a common phenomenon observed during treatment with antibacterials. Use of nanozymes, especially those synergistic enzyme-like activities, as antibacterials could overcome this problem, but their synthesis limited by high cost and/or complex production process. Herein, vanadium oxide nanodots (VOxNDs) were prepared via one-step bottom-up ethanol-thermal method using trichloride the precursor. VOxNDs alone possess bienzyme mimics peroxidase and oxidase. Accordingly, highly efficient against drug-resistant bacteria can be obtained through catalysis; oxidase-like activity decomposes O2 to generate superoxide anion radical (O2-) hydroxyl radicals (OH), intrinsic peroxidase-like further induce OH from external H2O2. Consequently, H2O2 concentration decrease up four magnitude orders achieve an antibacterial efficacy similar that alone. Wound healing in vivo confirms efficiency, good biocompatibility, application potential system due "nano" structure VOxNDs. The nanodot described paper inexpensive, results study reveal multi-enzymatic synergism nanozymes.