Decreased levels of serum nesfatin-1 in patients with obstructive sleep apnea syndrome.
作者： Peng Shen , Yingying Han , Bo Cai , Yu Wang
DOI: 10.1007/S11325-014-1039-0
关键词:
摘要: Recent evidences suggest that inflammation is involved in the mechanism of obstructive sleep apnea syndrome (OSAS). Nesfatin-1, recently identified as satiety regulator, implicated to possess an anti-inflammatory effect. The aim our study investigate whether serum levels nesfatin-1 are associated with presence and severity OSAS. A total 196 patients OSAS 104 healthy subjects were enrolled this study. Serum measured by enzyme-linked immunosorbent assay. showed significantly reduced than controls. Multivariable logistic regression analysis indicates inversely (odds ration (OR) 0.003, 95 % confidence interval (CI) 0.001 0.017; P < 0.001). decreased severe compared mild moderate patients. Spearman correlation correlated In addition, negatively body mass index (BMI) (r = −0.299, P < 0.001), waist–hip ratio (WHR) (r = −0.277, homeostasis model assessment insulin resistance (HOMA-IR) (r = −0.338, apnea–hypopnea (AHI) (r = −0.248, P < 0.001) Decreased
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