Dopaminergic function in relation to genes associated with risk for schizophrenia: translational mutant mouse models
作者： Paula M. Moran , Colm M.P. O'Tuathaigh , Francesco Papaleo , John L. Waddington
DOI: 10.1016/B978-0-444-63425-2.00004-0
关键词:
摘要: Mutant mice play an increasingly important role in understanding disease processes at multiple levels. In particular, they illuminate the impact of risk genes for on such processes. This article reviews recent advances application mutant to study intricacies dopaminergic (DAergic) function relation putative pathophysiology psychotic illness, particularly schizophrenia, and antipsychotic drug action. It considers models role(s) genes, with a particular focus DTNBP1 NRG1, their interactions environmental factors, each other (epistasis). overview, it new schemas illness that integrate DAergic developmental, social, cognitive processes, how mouse can reflect inform schemas.
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sci-hub.se 参考文章(222)
I. BERTRAM, H.-G. BERNSTEIN, U. LENDECKEL, A. BUKOWSKA, H. DOBROWOLNY, G. KEILHOFF, D. KANAKIS, C. MAWRIN, H. BIELAU, P. FALKAI, B. BOGERTS, Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression. Annals of the New York Academy of Sciences. ,vol. 1096, pp. 147- 156 ,(2007) , 10.1196/ANNALS.1397.080
Gregory V. Carr, Kimberly A. Jenkins, Daniel R. Weinberger, Francesco Papaleo, Loss of dysbindin-1 in mice impairs reward-based operant learning by increasing impulsive and compulsive behavior Behavioural Brain Research. ,vol. 241, pp. 173- 184 ,(2013) , 10.1016/J.BBR.2012.12.021
P. Seeman, S. Kapur, Schizophrenia: More dopamine, more D2 receptors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 7673- 7675 ,(2000) , 10.1073/PNAS.97.14.7673
Georg Winterer, Daniel R. Weinberger, Genes, dopamine and cortical signal-to-noise ratio in schizophrenia Trends in Neurosciences. ,vol. 27, pp. 683- 690 ,(2004) , 10.1016/J.TINS.2004.08.002
A.J Law, C Shannon Weickert, T.M Hyde, J.E Kleinman, P.J Harrison, Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain. Neuroscience. ,vol. 127, pp. 125- 136 ,(2004) , 10.1016/J.NEUROSCIENCE.2004.04.026
Ina Weiner, Michal Arad, Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment Behavioural Brain Research. ,vol. 204, pp. 369- 386 ,(2009) , 10.1016/J.BBR.2009.05.004
D. Vullhorst, J. Neddens, I. Karavanova, L. Tricoire, R. S. Petralia, C. J. McBain, A. Buonanno, Selective Expression of ErbB4 in Interneurons, But Not Pyramidal Cells, of the Rodent Hippocampus The Journal of Neuroscience. ,vol. 29, pp. 12255- 12264 ,(2009) , 10.1523/JNEUROSCI.2454-09.2009
Hiroaki Hori, Hiroko Noguchi, Ryota Hashimoto, Tetsuo Nakabayashi, Mayu Omori, Sho Takahashi, Ryotaro Tsukue, Kimitaka Anami, Naotsugu Hirabayashi, Seiichi Harada, Osamu Saitoh, Masao Iwase, Osami Kajimoto, Masatoshi Takeda, Shigeo Okabe, Hiroshi Kunugi, Antipsychotic medication and cognitive function in schizophrenia. Schizophrenia Research. ,vol. 86, pp. 138- 146 ,(2006) , 10.1016/J.SCHRES.2006.05.004
Damiana Leo, Raul R. Gainetdinov, Transgenic mouse models for ADHD Cell and Tissue Research. ,vol. 354, pp. 259- 271 ,(2013) , 10.1007/S00441-013-1639-1
R TANDON, M KESHAVAN, H NASRALLAH, Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology Schizophrenia Research. ,vol. 102, pp. 1- 18 ,(2008) , 10.1016/J.SCHRES.2008.04.011