Pneumocystis carinii pneumonia as a complication of bendamustine monotherapy in a patient with advanced progressive breast cancer
作者： A. Klippstein , C. P. Schneider , H. G. Sayer , K. Höffken
DOI: 10.1007/S00432-003-0441-Y
关键词:
摘要: Background Bendamustine is an alkylator with anticipated antimetabolic activity. It has shown activity in malignant lymphoma, multiple myeloma, and breast cancer. Recognized side-effects are relatively mild myelosuppression as the dose-limiting toxicity. The CD4/CD8 ratio may be reduced. To what extent alteration of lymphocytes, especially CD4+ correlates increase opportunistic infections cannot definitively answered.
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sci-hub.se 参考文章(15)
Dirk Strumberg, Andreas Harstrick, Kathia Doll, Britta Hoffmann, Siegfried Seeber, Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines Anti-Cancer Drugs. ,vol. 7, pp. 415- 421 ,(1996) , 10.1097/00001813-199606000-00007
B. Brockmann, Evelyn Geschke, Uta-Maria Schmidt, K. Ebeling, Therapieergebnisse und toxische Nebenwirkungen der Kombination Cytostasan, Adriamycin und Vincristin als „Second line“-Therapie beim metastasierten Mammakarzinom Geburtshilfe Und Frauenheilkunde. ,vol. 51, pp. 383- 386 ,(1991) , 10.1055/S-2007-1026163
James Siminski, Pamela Kidd, Gretchen D. Phillips, Carolyn Collins, Ganesh Raghu, Reversed Helper/Suppressor T-Lymphocyte Ratio in Bronchoalveolar Lavage Fluid from Patients with Breast Cancer andPneumocystis cariniiPneumonia American Review of Respiratory Disease. ,vol. 143, pp. 437- 440 ,(1991) , 10.1164/AJRCCM/143.2.437
P. Schöffski, T. Hagedorn, V. Grünwald, H. Paul, K. Merkle, R. Kowalski, A. Ganser, Repeated administration of short infusions of bendamustine: a phase I study in patients with advanced progressive solid tumours. Journal of Cancer Research and Clinical Oncology. ,vol. 126, pp. 41- 47 ,(2000) , 10.1007/PL00008463
R. Kath, K. Blumenstengel, H. J. Fricke, K. Höffken, Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia Journal of Cancer Research and Clinical Oncology. ,vol. 127, pp. 48- 54 ,(2001) , 10.1007/S004320000180
G. Flandrin, H. Dombret, D. Poisson, L. Degos, S. Castaigne, J. N. Bastie, D. Cazals-Hatem, M. T. Daniel, M. F. D'agay, CL. Rabian, S. Glaisner, M. P. Noel-Walter, D. Dabout, Five years follow-up after 2-chloro deoxyadenosine treatment in thirty patients with hairy cell leukemia: evaluation of minimal residual disease and CD4+ lymphocytopenia after treatment. Leukemia & Lymphoma. ,vol. 35, pp. 555- 565 ,(1999) , 10.1080/10428199909169620
P. W. Wijermans, W. B. J. Gerrits, H. L. Haak, Severe immunodeficiency in patients treated with fludarabine monophosphate European Journal of Haematology. ,vol. 50, pp. 292- 296 ,(2009) , 10.1111/J.1600-0609.1993.TB00165.X
G.C. Kane, M.B. Troshinsky, S.P. Peters, H.L. Israel, Pneumocystis carinii pneumonia associated with weekly methotrexate: cumulative dose of methotrexate and low CD4 cell count may predict this complication. Respiratory Medicine. ,vol. 87, pp. 153- 155 ,(1993) , 10.1016/0954-6111(93)90146-Q
K. Höffken, Kh. Merkle, M. Schönfelder, G. Anger, M. Brandtner, K. Ridwelski, S. Seeber, Bendamustine as salvage treatment in patients with advanced progressive breast cancer: a phase II study Journal of Cancer Research and Clinical Oncology. ,vol. 124, pp. 627- 632 ,(1998) , 10.1007/S004320050225
Angelika N. Rahn, R. Burkhart Schilcher, Irenäus A. Adamietz, Stephan Mose, Sabine B. Bormeth, Heinz D. Böttcher, Palliative Radiochemotherapie mit Bendamustin bei fortgeschrittenen Tumorrezidiven im HNO-Bereich Strahlentherapie Und Onkologie. ,vol. 177, pp. 189- 194 ,(2001) , 10.1007/PL00002397