Synthesis of trifluoroalkyl or difluoroalkyl phenanthridine derivatives via cascade reaction using an intramolecular cyano group as a radical acceptor under photoredox catalysis
作者： Xu Liu , Zhongjie Wu , Zeguo Zhang , Ping Liu , Peipei Sun
DOI: 10.1039/C7OB02804K
关键词:
摘要: In the presence of Ru(phen)3Cl2 or fac-Ir(ppy)3 under visible-light irradiation, addition fluorinated radicals to N-arylacrylamides followed by an intramolecular cyano group insertion cascade cyclization process produced trifluoroalkyl difluoroalkyl phenanthridine derivatives in moderate good yields. Three easily available fluoroalkylated reagents CF3SO2Cl, BrCF2CO2Et and BrCF2PO(OEt)2 were used as sources radicals.
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