Standardized fluorescence in situ hybridization testing based on an appropriate panel of probes more effectively identifies common cytogenetic abnormalities in myelodysplastic syndromes than conventional cytogenetic analysis: a multicenter prospective study of 2302 patients in China.
作者： Yue-Yun Lai , Xiao-Jun Huang , Juan Li , Ping Zou , Ze-Feng Xu
DOI: 10.1016/J.LEUKRES.2015.02.005
关键词:
摘要: In an attempt to establish the advantages of fluorescence in situ hybridization (FISH) studies over conventional cytogenetic (CC) analysis, a total 2302 de novo MDS patients from 31 Chinese institutions were prospectively selected present study for both CC and standardized FISH analysis +8, -7/7q-, -5/5q-, 20q- and-Y chromosomal abnormalities. was successful 94.0% patients; these patients, 35.9% cases abnormal. all detected at least one type common abnormality 42.7% cases. The incidences abnormalities by 4.1% 8.7% higher than those CC. identified 23.6% exhibiting normal results revealed that 20.7% with adequate metaphases (≥20) had abnormal clones. 50.4% failed analysis. summary, our multicenter emphasised confirmed importance applying testing based on appropriate panel probes detect particularly or results.
elsevier.com
sci-hub.se 参考文章(25)
Katarzyna Skonieczka, Ewa Duszeńko, Elżbieta Wyrowińska, Olga Haus, Usefulness of classic cytogenetic testing compared to fluorescence in situ hybridization in genetic diagnosis of 58 patients with myelodysplastic syndromes. Polskie Archiwum Medycyny Wewnetrznej-polish Archives of Internal Medicine. ,vol. 119, pp. 366- 372 ,(2009) , 10.20452/PAMW.711
Peter Greenberg, Christopher Cox, Michelle M. LeBeau, Pierre Fenaux, Pierre Morel, Guillermo Sanz, Miguel Sanz, Teresa Vallespi, Terry Hamblin, David Oscier, Kazuma Ohyashiki, Keisuke Toyama, Carlo Aul, Ghulam Mufti, John Bennett, International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes Blood. ,vol. 89, pp. 2079- 2088 ,(1997) , 10.1182/BLOOD.V89.6.2079
Olga Pozdnyakova, Patricia M. Miron, Guilin Tang, Otto Walter, Azra Raza, Bruce Woda, Sa A. Wang, Cytogenetic abnormalities in a series of 1029 patients with primary myelodysplastic syndromes Cancer. ,vol. 113, pp. 3331- 3340 ,(2008) , 10.1002/CNCR.23977
Daynna J Wolff, Adam Bagg, Linda D Cooley, Gordon W Dewald, Betsy A Hirsch, Peter B Jacky, Kathleen W Rao, P Nagesh Rao, Association for Molecular Pathology Clinical Practice Committee, American College of Medical Genetics Laboratory Quality Assurance Committee, Guidance for Fluorescence in Situ Hybridization Testing in Hematologic Disorders The Journal of Molecular Diagnostics. ,vol. 9, pp. 134- 143 ,(2007) , 10.2353/JMOLDX.2007.060128
Vera Ademà, Jesús María Hernández, María Abáigar, Eva Lumbreras, Esperanza Such, Anna Calull, Esther Dominguez, Leonor Arenillas, Mar Mallo, José Cervera, Isabel Marugán, Mar Tormo, Francisca García, Teresa González, Elisa Luño, Carmen Sanzo, María Luisa Martín, Manuela Fernández, Dolors Costa, Beatriz Blázquez, Beatriz Barreña, Fernando Marco, Ana Batlle, Ismael Buño, Carolina Martínez-Laperche, Víctor Noriega, Rosa Collado, David Ivars, Félix Carbonell, Isabel Vallcorba, Josefa Melero, Elena Delgado, María Teresa Vargas, Javier Grau, Marta Salido, Blanca Espinet, Carme Melero, Lourdes Florensa, Carmen Pedro, Francesc Solé, None, Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: Does −7/7q− detection by FISH have prognostic value? Leukemia Research. ,vol. 37, pp. 416- 421 ,(2013) , 10.1016/J.LEUKRES.2012.12.010
Athena M. Cherry, Stephanie R. Brockman, Sarah F. Paternoster, Gary A. Hicks, Donna Neuberg, Rodney R. Higgins, John M. Bennett, Peter L. Greenberg, Kenneth Miller, Martin S. Tallman, Jacob Rowe, Gordon W. Dewald, Comparison of interphase FISH and metaphase cytogenetics to study myelodysplastic syndrome: an Eastern Cooperative Oncology Group (ECOG) study Leukemia Research. ,vol. 27, pp. 1085- 1090 ,(2003) , 10.1016/S0145-2126(03)00104-8
Richard D. Irons, Xiaoqin Wang, Sherilyn A. Gross, Liming Bao, John Ryder, Yan Chen, Hui Chen, Hengjuan Sun, Jue Zhou, Meirong Ji, Xinyu Du, Hua Fu, Guowei Lin, Prevalence of MDS subtypes in Shanghai, China: A comparison of the World Health Organization and French American British classifications Leukemia Research. ,vol. 30, pp. 769- 775 ,(2006) , 10.1016/J.LEUKRES.2005.10.018
Joshua F. Coleman, Karl S. Theil, Raymond R. Tubbs, James R. Cook, Diagnostic yield of bone marrow and peripheral blood FISH panel testing in clinically suspected myelodysplastic syndromes and/or acute myeloid leukemia: a prospective analysis of 433 cases. American Journal of Clinical Pathology. ,vol. 135, pp. 915- 920 ,(2011) , 10.1309/AJCPW10YBRMWSWYE
P Bernasconi, P M Cavigliano, M Boni, S Calatroni, C Klersy, I Giardini, B Rocca, N Crosetto, M Caresana, M Lazzarino, C Bernasconi, Is FISH a relevant prognostic tool in myelodysplastic syndromes with a normal chromosome pattern on conventional cytogenetics? A study on 57 patients. Leukemia. ,vol. 17, pp. 2107- 2112 ,(2003) , 10.1038/SJ.LEU.2403108
B Chen, W-L Zhao, J Jin, Y-Q Xue, X Cheng, X-T Chen, J Cui, Z-M Chen, Q Cao, G Yang, Y Yao, H-L Xia, J-H Tong, J-M Li, J Chen, S-M Xiong, Z-X Shen, S Waxman, Z Chen, S-J Chen, Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries. Leukemia. ,vol. 19, pp. 767- 775 ,(2005) , 10.1038/SJ.LEU.2403688