Mast Cell Modulation of the Innate Immune Response to Enterobacterial Infection

摘要: Although mast cells have been associated with many biological responses (e.g. inflammation, tissue repair and angiogenesis) clinical conditions rheumatoid arthritis, interstitial cystitis, scleroderma, psoriasis, neurofibromatosis Crohn’s disease), they remain one of the least understood immune system. By virtue their high affinity IgE/F ceRI-receptors intrinsic capacity to release large amounts inflammatory mediators, are primary known as major effector allergy or type 1 hypersensitivity reactions (Marone et al 1997). In spite these deleterious properties, preserved through evolution even among lowest orders animals indicating that must be serving a valuable function in body. A number factors suggest role for modulating innate response against bacteria. These include fact present numbers under epithelia various mucosal surfaces skin. They also mobilize rapid vigorous host upon activation already shown contribute certain aspects IgE-mediated adaptive parasites (Levy &