Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients

摘要: Introduction: Cryptococcal meningoencephalitis (CM) is a rare infection in pediatric patients, which associated with substantial morbidity and mortality. Since symptoms of this are nonspecific, the diagnosis relies on risk assessment laboratory-confirmed clinical findings. Initial management commonly utilizes amphotericin B flucytosine, followed by prolonged fluconazole to clear yeast prevent relapse. no prospective trials have been performed much data extrapolated from adult studies pharmacokinetic data. This highlights need for review additional studies. Areas covered: Here, pathophysiology, epidemiology, presentation treatment CM patients described. Additionally, relative safety differences pharmacologic between highlighted. Expert opinion: Guidelines are...