Layered Double Hydroxide: A New Ceramic-Based Hemostatic Agent?

摘要: Layered double hydroxides (LDHs), well known as anionic clays or hydrotalcite-like compounds consist of positively charged layers. Net positive charges on the layers are balanced by exchangeable anions along with water molecules in interlayer space. In present research, potential for use Ca/Al-LDH local hemostatic agent is evaluated vitro measuring coagulation time human fresh blood presence LDH powder. Crystalline powders required these experiments were synthesized via a co-precipitation method followed controlled hydrothermal process using calcium nitrate and aluminum starting materials under certain synthetic conditions such concentration. XRD SEM analyses utilized to characterize powders. results demonstrate crystalline pure hexagonal morphology. order investigate biocompatibility samples, culture techniques employed mouse fibroblast cells (L929) reference cell line. The reveal that powder can accelerate platelet aggregation formation clot. Moreover, samples show good proliferation high viability L929 line compared negative control sample. These layered suitable candidates hemorrhage reduce loss lethal injuries. INTRODUCTION Uncontrolled bleeding consequent hemorrhagic shock leading causes death many injuries early improve outcome [1-2]. minor accidents, may be body's own clotting mechanisms. But more severe wounds, additional controls applying pressure absorbent dressings pads required. methods ineffective bleedings persons lessened One efficient way form powder, foam, pad, etc. at source bleeding. Limited [3]. Such an must safe, rapidly effective have systemic compatibility [4]. Several fibrin-based, collagen-based, cellulose-based gelatin-based [4-7] systems been introduced agents. While bleeding, they expensive. A newer –commercially named QuikClot ® zeolite-based shows different sources [1-2, 8-9]. Zeolites family Silicates one most abundant classes minerals Earth. Clays group inorganic structural similarities zeolites [10]. Double Hydroxides also called compounds, clay-like promising properties large number applications. (LDHs) over 150 years since discovery mineral hydrotalcite. They broad class lamellar capacity anion intercalation. structure -represented [M 2+ 1-xM 3+ x(OH)2] x+ (A n)x/n·mH2Oresults from stacking brucite-like ([Mg(OH)2]) containing extra charge due partial isomorphous substitution M . This excess anions, which exist interlamellar spaces [1-3]. display unique physical Page 1 5