Seroprevalence of SARS-CoV-2, symptom profiles and seroneutralization during the first COVID-19 wave in a suburban area, France

摘要: Abstract Background The World Health Organisation recommends monitoring the circulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to estimate anti–SARS-CoV-2 total immunoglobulin (IgT) antibody seroprevalence and describe symptom profiles in vitro seroneutralization Nancy, France, spring 2020. Methods Individuals were randomly sampled from electoral lists invited with household members over 5 years old be tested for (IgT, i.e. IgA/IgG/IgM) antibodies by ELISA (Bio-rad). Serum samples classified according activity >50% (NT50) on Vero CCL-81 cells. Age- sex-adjusted was estimated. Subgroups compared chi-square or Fisher exact test logistic regression. Results Among 2006 individuals, 43 SARS-CoV-2–positive; raw 2.1% (95% confidence interval 1.5 2.9), adjusted metropolitan national standardized 2.5% (1.8 3.3) 2.3% (1.7 3.1). Seroprevalence highest 20-to 34-year-old participants (4.7% [2.3 8.4]), within than out socially deprived area (2.5% vs 1%, P=0.02) without intra-family infection (p Conclusions In this population very low anti-SARS-CoV-2 seroprevalence, a beneficial effect lockdown can assumed, frequent SARS-CoV-2 among IgT-positive patients. Key Messages Total measurement is an accurate tool monitor (SARS-CoV-2) key biological feature assume spread COVID-19 later after appearance symptoms. IgT Grand Nancy Metropolitan area, France; young adults; but not confirmed at individual level; associated high viral transmission. About two thirds individuals exhibited SARS-CoV-2–positive seroneutralization. Trial registration NCT04448769