In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell--endothelial cell interaction.

作者: Peter Gassmann , Mi-Li Kang , Soeren T Mees , Joerg Haier

DOI: 10.1186/1471-2407-10-177

关键词:

摘要: Background Metastasis formation is the leading cause of death among colon cancer patients. We established a new in-situ model in vivo microscopy lung to analyse initiating events metastatic tumor cell adhesion within this typical target cancer.

参考文章(57)
M. I. Bird, M. R. Foster, R. Priest, R. Malhotra, Selectins: physiological and pathophysiological roles. Biochemical Society Transactions. ,vol. 25, pp. 1199- 1206 ,(1997) , 10.1042/BST0251199
F. William Orr, H. Helen Wang, Tumor cell interactions with the microvasculature: a rate-limiting step in metastasis. Surgical Oncology Clinics of North America. ,vol. 10, pp. 357- 381 ,(2001) , 10.1016/S1055-3207(18)30070-X
Felix Rosenow, Rainer Ossig, Dorit Thormeyer, Peter Gasmann, Kerstin Schlüter, Georg Brunner, Jörg Haier, Johannes A. Eble, Antimetastatic Integrin as Inhibitors of Snake Venoms Neoplasia. ,vol. 10, pp. 168- 176 ,(2008) , 10.1593/NEO.07898
A.B. Al-Mehdi, K. Tozawa, A.B. Fisher, L. Shientag, A. Lee, R.J. Muschel, Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Medicine. ,vol. 6, pp. 100- 102 ,(2000) , 10.1038/71429
H.P. Vollmers, B.A. Imhof, S. Braun, C.A. Waller, V. Schirrmacher, W. Birchmeier, Monoclonal antibodies which prevent experimental lung metastases. Interference with the adhesion of tumour cells to laminin. FEBS Letters. ,vol. 172, pp. 17- 20 ,(1984) , 10.1016/0014-5793(84)80863-7
Sen-itiroh Hakomori, Tumor Malignancy Defined by Aberrant Glycosylation and Sphingo(glyco)lipid Metabolism Cancer Research. ,vol. 56, pp. 5309- 5318 ,(1996)
Kenji Shibuya, Colin D Mathers, Cynthia Boschi-Pinto, Alan D Lopez, Christopher JL Murray, None, Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000 BMC Cancer. ,vol. 2, pp. 37- 37 ,(2002) , 10.1186/1471-2407-2-37
L Weiss, E Grundmann, J Torhorst, F Hartveit, I Moberg, Mea Eder, CM Fenoglio‐Preiser, J Napier, CHW Horne, MJ Lopez, RI Shaw‐Dunn, J Sugar, JD Davies, DW Day, JP Harlos, None, Haematogenous metastastic patterns in colonic carcinoma: An analysis of 1541 necropsies The Journal of Pathology. ,vol. 150, pp. 195- 203 ,(1986) , 10.1002/PATH.1711500308
Anke von Sengbusch, Peter Gassmann, Katja M. Fisch, Andreas Enns, Garth L. Nicolson, Jörg Haier, Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. American Journal of Pathology. ,vol. 166, pp. 585- 596 ,(2005) , 10.1016/S0002-9440(10)62280-8