Acylguanidine derivative or salt thereof
作者： Hirotsune Itahana , Eisuke Nozawa , Takaho Matsuzawa , Koichiro Harada , Ayako Moritomo
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摘要: It is intended to provide a compound which can be used for preventing and/or treating disease associated with 5HT2B receptor and 5HT7 receptor, particularly irritable bowel syndrome (IBS) migraine. was found that an acylguanidine derivative characterized by having tricyclic structure or pharmaceutically acceptable salt thereof has strong antagonism receptor. In addition, the of invention both receptors showed better pharmacological action compared case where antagonist selective one solely used. From above results, useful
lens.org 参考文章(55)
Hiroyoshi Yamada, Toshihiro Watanabe, Hiroyuki Ito, Shinobu Akuzawa, Medicament For Irritable Bowel Syndrome ,(2006)
Shinobu Akuzawa, Toshihiro Watanabe, Prophylactic antimigraine agents ,(2005)
Jean-Louis Vidaluc, Dennis Bigg, New urea derivatives, their preparation and their application in therapy ,(1992)
Serge Mignani, Jean Bououerel, Jean-Christophe Carry, Pascal Desmazeau, Heinz-Werner Kleemann, Baptiste Ronan, Arielle Genevois-Borella, Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them ,(2003)
Douglas A. Craig, Use of agonists or antagonists of the 5-HT7 receptor to treat disorders of the bladder ,(2000)
Seetharamaiyer Padmanabhan, Graham J. Durant, Pharmaceutically active compounds and methods of use ,(1997)
Jeremiah Harnett, Gérard Ulibarri, Serge Auvin, Pierre-Etienne Chabrier de Lassauniere, Dennis Bigg, N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them ,(1999)
Wenrong Huang, Yonghong Song, James Kanter, Bing-Yan Zhu, Zhaozhong Jon Jia, Robert M. Scarborough, Inhibitors of factor xa ,(2000)
Masafumi Kitano, Atsuyuki Kojima, Kazuhiro Nakano, Akira Miyagishi, Tsuyoshi Noguchi, Naohito Ohashi, Synthesis and Biological Activity of N‐(Aminoiminomethyl)‐1H‐indole Carboxamide Derivatives as Na+/H+ Exchanger Inhibitors. ChemInform. ,vol. 31, ,(2000) , 10.1002/CHIN.200016114
Bishwa R Tuladhar, Lanbo Ge, Robert J Naylor, 5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum. British Journal of Pharmacology. ,vol. 138, pp. 1210- 1214 ,(2003) , 10.1038/SJ.BJP.0705184