A prophylactic multi-strain probiotic treatment to reduce the absorption of toxic elements: In-vitro study and biomonitoring of breast milk and infant stools

摘要: Abstract Potential exposure to toxic elements initially occurs during gestation and after birth via breast milk, which is the principal source of nutrients for infants first months life. In this study, we evaluated whether maternal oral supplementation with a multi-strain probiotic product can protect from arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb) milk. In-vitro studies bacterial strains present in showed high tolerance As, Cd, Hg, Pb, good binding capacity Pb (72%, 81%, 64%, respectively) within 1 h contact. We concentrations (5 mg L−1 Cd 2 mg L−1 Hg) that largely exceeded provisional tolerable weekly intake these food or water applicable human consumption. Changes levels milk newborn stools were control (orally supplemented placebo) experimental probiotic) groups at (t0), 15 days (t15), 30 days (t30) delivery. Elemental analysis did not show significant differences between different stages lactation; however, stool samples obtained newborns mothers significantly reduced (by 26%) t15 compared controls. Our data an association concentration stools. Indeed, decreased lactation period, whereas stable over time. Although our in-vitro indicate consortium absorb compounds, study was limited by its small sample size potential uncontrolled confounding effects, such as diet lifestyle. Therefore, could confirm prophylactic use reduce absorption elements. The risk assessment studied population evidenced margin (MOE) 1, 1 10 lower than 50 As. This poses breastfed infants, indicating interventions aimed avoid breastfeeding-related health risks remain major challenge public health.