Abnormal primary tissue collagen composition in the skin of recurrent incisional hernia patients.

摘要: Recurrence of incisional hernia may be as high 50 per cent. Abnormal collagen I/III ratios have been observed within scar tissue patients with recurrent hernias. We sought to determine whether composition in primary, nonscarred was similarly affected these patients. In this prospective, case-control study, nonscarred, primary abdominal wall skin and fascia biopsies were obtained 12 a history hernias 11 control subjects without any while undergoing laparoscopic surgery. Tissue protein expression I III assessed by immunohistochemistry followed densitometry analysis. The ratio from the group significantly less compared (0.88 +/- 0.01 versus 0.98 0.04, respectively, P < 0.05). Fascia not decreased (0.90 0.04 0.94 0.03, = 0.17). Decreased involved or healing suggest an underlying defect. Such defect, addition abnormal formation, likely plays significant role pathogenesis