The Level of Selenium and Oxidative Stress in Workers Chronically Exposed to Lead.

作者: Natalia Pawlas , Michał Dobrakowski , Aleksandra Kasperczyk , Agnieszka Kozłowska , Agnieszka Mikołajczyk

DOI: 10.1007/S12011-015-0435-Z

关键词:

摘要: The possible beneficial role of selenium (Se) on the oxidative stress induced by lead (Pb) is still unclear in humans. Therefore, aim present study was to explore associations among Se levels, chronic Pb exposure, parameters, and parameters characterizing function antioxidant defense system men who are occupationally exposed Pb. Based median serum concentrations, 324 subjects were divided into two subgroups: a subgroup with low level (L-Se) high (H-Se). levels (PbB) zinc protoporphyrin (ZPP) blood delta-aminolevulinic acid (ALA) urine served as indices exposure. PbB significantly lower H-Se group compared that L-Se 6 %. 8-hydroxyguanosine lipofuscin (LPS) activity superoxide dismutase 17, 19, 11 %, respectively. However, glutathione (GSH) activities peroxidase (GPx) catalase higher 9, 23, 3 %. Spearman correlations showed positive between GPx GSH level. A chronically Pb-exposed associated an elevated erythrocyte LPS level, which reflects intensity stress. Besides, depleted pool decreased erythrocytes reported. results inadequate recommend supplementation for exposure at doses than would be included normal diet except deficiency.

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