On the human sensorimotor-cortex beta rhythm: sources and modeling

摘要: Cortical oscillations in the beta band (13-35 Hz) are known to be modulated by GABAergic agonist benzodiazepine. To investigate mechanisms generating approximately 20-Hz human cortex, we administered benzodiazepines healthy adults and monitored cortical oscillatory activity means of magnetoencephalography. Benzodiazepine increased power decreased frequency over rolandic areas. Minimum current estimates indicated effect take place around hand area primary sensorimotor cortex. Given that previous research has identified sources rhythm motor our results suggest these same motor-cortex explore underlying increase with inhibition, simulated a conductance-based neuronal network comprising excitatory inhibitory neurons. The model accounts for power, widening spectral peak, slowing down rhythms benzodiazepines, implemented as an conductance. We found IPSCs onto neurons was more important synchronization than pyramidal cells.