The role of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma.
作者： Buhle Moyo , Samantha A. Nicholson , Patrick B. Arbuthnot
DOI: 10.1016/J.VIRUSRES.2015.07.025
关键词:
摘要: Chronic infection with hepatitis B virus (HBV) is a major risk for development of hepatocellular carcinoma (HCC), which the fifth most common cancer and leading global cause mortality. Long noncoding RNAs (lncRNAs) are regulators complex biological processes their functional disruption implicated in etiology many cancers including HCC. Several lncRNAs have been shown to oncogenic or tumor suppressive roles recently become focus intense investigation. However, contributions HBV-related HCC remain be fully elucidated. In this review we concentrate on various HBV-associated Their involvement viral replication, specific association certain HCC, potential utility as therapeutic targets diagnostic markers discussed.
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