Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies

摘要: A therapeutic method of modulating the immune response, by administering to a patient an amount IL-4 effective promote peripheral blood lymphocyte adhesion microvascular endothelial cells in lymphoid organs. The is preferably coadministered with IL-1β. An improved screening cell line for production binding partner that binds molecule, contacting IL4-activated and nonactivated cells, selecting partners bind but not cells. selected may thereafter be tested ability block cytokine-activated are also characterized human VCAM-1 IL4- or TNFα-activated bone marrow stromal representative embodiment mAb 6G10 produced hybridoma ATTC No. HB10519. response patient, agent specifically impede transmigration lymphocytes from across postcapillary venules.