Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: An in vitro comparative study

摘要: Abstract Human immunodeficiency virus type 1 (HIV-1) strains were isolated from nine patients before and after prolonged therapy with either an alternating regimen of 3'-azido-3'-deoxythymidine (AZT) 2',3'-dideoxycytidine (ddC) (AZT/ddC) or 2',3'-dideoxyinosine (ddI) alone. All obtained four who received AZT/ddC for up to 41 mo highly insensitive AZT in vitro. Only one strain showed reduced susceptibility ddC addition had previously unreported amino acid substitutions the viral polymerase-encoding pol region, whereas three other more five reported AZT-related mutations. In HIV-1 ddI 29 mo, no appreciable decrease sensitivity was detected. Two significant mutations, although a mutation reportedly associated administration. These data suggest that develops readily than and/or is modest degree. Moreover, present does not block emergence AZT-insensitive variants. It should be noted, however, current results do provide basis concluding inferior, equivalent, superior as AIDS.