Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy

摘要: Abstract Background G protein-coupled estrogen receptor 1 (GPER-1) has been demonstrated in several parts of the brain and may play an important role downstream signaling pathway. However, effects this on epileptic seizure are not clearly known. Therefore, GPER-1 agonist, G-1, antagonist, G-15 main estrogenic hormone, 17β-estradiol were investigated seizures tissue oxidative damages induced by pentylenetetrazole (PTZ) rats. Methods In study, 30 adult male Wistar albino rats used. Due to intraperitoneal ( ip ) injections a subconvulsant dose PTZ (35 mg/kg) which was repeated 12 times every 48 h, chemical kindling occurred recorded for 30 min. The injected with (5 μg/kg, or G-1 ), Saline, Ethanol Dimethyl sulfoxide (DMSO) 30 min before each PTZ. Observed classified between phase 0–5. Thirty minutes later when last 12. administration, all sacrificed cortex, hippocampus sections removed superoxide dismutase (SOD), malondialdehyde (MDA) nitric oxide (NO) levels these tissues studied. Results GPER1 significantly increased development seizures. did change cortex homogenates, NO after administration had p Conclusions This is first study that explores receptors have epileptogenic effect PTZ-induced rat. mediate estrogens changing anti-oxidative parameters brain.