The Internalization and Intracellular Processing of Insulin Receptors

摘要: Publisher Summary This chapter reviews the studies that provide evidence for internalization and cellular processing of insulin receptors in various target cells. It focuses on carried out isolated adipocytes using vitro binding assays photoaffinity labeling procedures. Receptor-mediated endocytosis is a process by which cells internalize variety molecules, including polypeptide hormones, nutrients, plasma transport proteins, antibodies. The intracellular pathway taken these different ligands similar involves sequestration within smooth or coated vesicles followed fusion with membrane eventual delivery ligand to lysosomes. receptor enter cell together. discusses receptors, recycling internalized back membrane, degradation speculations about functional significance processes Internalization insulin–receptor complexes may have roles overall action insulin. Internalized accumulates Golgi nuclear compartments. Therefore, it possible following internalization, would be transported organelles where binds structures regulates function activities.