X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod type
作者： Susumu Ohno , Mary F. Lyon
DOI: 10.1111/J.1399-0004.1970.TB01627.X
关键词:
摘要: Testosterone and 5 α-dihydrotestosterone normally induce alcohol dehydrogenase (ADH) production in the mouse kidney. The following results suggest that X-linked testicular feminization (T fm) mutation is a non-inducible of repressive regulatory gene locus. Eleven affected XTfmY mice 3 XTfm X+ heterozygous females, as well their normal sibs, were challenged with 10 mg either testosterone or 5α-dihydrotestosterone killed days later. Kidney ADH sibs fully induced state, while no detectable kidney activity was found XTemY. In accordance X-inactivation hypothesis, individual kidneys females showed extremely variable degrees inducibility ADH.
sci-hub.se 参考文章(15)
Senmaw Fang, K.M. Anderson, Shutsung Liao, Receptor Proteins for Androgens ON THE ROLE OF SPECIFIC PROTEINS IN SELECTIVE RETENTION OF 17β-HYDROXY-5α-ANDROSTAN-3-ONE BY RAT VENTRAL PROSTATE IN VIVO AND IN VITRO Journal of Biological Chemistry. ,vol. 244, pp. 6584- 6595 ,(1969) , 10.1016/S0021-9258(18)63447-7
G. M. Tomkins, E. B. Thompson, S. Hayashi, T. Gelehrter, D. Granner, B. Peterkofsky, Tyrosine Transaminase Induction in Mammalian Cells in Tissue Culture Cold Spring Harbor Symposia on Quantitative Biology. ,vol. 31, pp. 349- 360 ,(1966) , 10.1101/SQB.1966.031.01.045
E. Beutler, M. Yeh, V. F. Fairbanks, THE NORMAL HUMAN FEMALE AS A MOSAIC OF X-CHROMOSOME ACTIVITY: STUDIES USING THE GENE FOR G-6-PD-DEFICIENCY AS A MARKER Proceedings of the National Academy of Sciences of the United States of America. ,vol. 48, pp. 9- 16 ,(1962) , 10.1073/PNAS.48.1.9
FRANK S. FRENCH, JUDSON J. VAN WYK, BILLY BAGGETT, WILLIAM E. EASTERLING, LUTHER M. TALBERT, ROSS F. JOHNSTON, ENRICO FORCHIELLI, ARUN C. DEY, Further Evidence of a Target Organ Defect in the Syndrome of Testicular Feminization The Journal of Clinical Endocrinology and Metabolism. ,vol. 26, pp. 493- 503 ,(1966) , 10.1210/JCEM-26-5-493
MARY F. LYON, Gene Action in the X -chromosome of the Mouse ( Mus musculus L.) Nature. ,vol. 190, pp. 372- 373 ,(1961) , 10.1038/190372A0
Susumu Ohno, Christina Stenius, Larry Christian, Cephas Harris, Chris Ivey, More about the testosterone induction of kidney alcohol dehydrogenase activity in the mouse Biochemical Genetics. ,vol. 4, pp. 565- 577 ,(1970) , 10.1007/BF00486095
C. W. Bardin, L. Bullock, G. Schneider, J. E. Allison, A. J. Stanley, Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone Science. ,vol. 167, pp. 1136- 1137 ,(1970) , 10.1126/SCIENCE.167.3921.1136
Peter Karlson, New concepts on the mode of action of hormones. Perspectives in Biology and Medicine. ,vol. 6, pp. 203- 214 ,(1963) , 10.1353/PBM.1963.0026
M. G. Rosenfeild, B. W. O'Malley, Steroid Hormones: Effects on Adenyl Cyclase Activity and Adenosine 3',5'-Monophosphate in Target Tissues Science. ,vol. 168, pp. 253- 255 ,(1970) , 10.1126/SCIENCE.168.3928.253
P. Mauvais-Jarvis, J. P. Bercovici, O. Crepy, F. Gauthier, Studies on testosterone metabolism in subjects with testicular feminization syndrome Journal of Clinical Investigation. ,vol. 49, pp. 31- 40 ,(1970) , 10.1172/JCI106219