Docetaxel-Loaded Chitosan-Cholesterol Conjugate-Based Self-Assembled Nanoparticles for Overcoming Multidrug Resistance in Cancer Cells
作者： Chao-Feng Mu , Fude Cui , Yong-Mei Yin , Hyun-Jong Cho , Dae-Duk Kim
DOI: 10.3390/PHARMACEUTICS12090783
关键词:
摘要: Cholesteryl hemisuccinate (CHS)-conjugated chitosan (CS)-based self-assembled nanoparticles (NPs) were developed for enhancing the intracellular uptake of docetaxel in multidrug resistance (MDR)-acquired cancer cells. CHS-CS was successfully synthesized and self-aggregation, particle size, zeta potential, drug entrapment efficiency, vitro release docetaxel-loaded NPs tested. The optimized had a mean hydrodynamic diameter 303 nm, positive potential 21.3 mV, spherical shape. from different pH medium (pH 6.0 7.4) revealed that improved more acidic condition 6.0), representing tumor cell's environment. superior MDR-overcoming effect NPs, compared with solution, verified anti-proliferation cellular accumulation studies MDR-acquired KBV20C Thus, could be potentially used overcoming MDR anticancer delivery.
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