Resveratrol Attenuates Microglial Activation via SIRT1-SOCS1 Pathway.

摘要: Microglial activation is involved in a variety of neurological disorders, and overactivated microglial cells can secrete large amount proinflammatory factors induce neuron death. Therefore, reducing believed to be useful treating the disorders. In this study, we used 10 ng/ml lipopolysaccharide plus 10 U/ml interferon γ (LPS/IFNγ) N9 explored resveratrol- (RSV-) induced effects on underlying mechanism. We found that LPS/IFNγ exposure for 24 h increased inducible nitric oxide synthase (iNOS) nuclear factor κB (NF-κB) p65 subunit expressions enhanced tumor necrosis α (TNF-α) interleukin 1β (IL-1β) releases from cells. RSV 25 μM reduced iNOS NF-κB factors’ releases; knockdown silent information regulator 2-related enzyme 1 (SIRT1) or suppressor cytokine signaling (SOCS1) by using small interfering RNA, however, significantly abolished RSV-induced releases. These findings showed SIRT1-SOCS1 pathway may mediate inhibition LPS/IFNγ-treated microglia.