Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome: Efficacy of long-term continuous therapy

摘要: Thirty-five patients with the acquired immunodeficiency syndrome (AIDS) and central nervous system toxoplasmosis, seen over a 30-month period, were treated combination pyrimethamine/sulfadiazine. All had clinical computed tomographic scan findings consistent active neurotoxoplasmosis. Mean duration of total therapy was six months. During first two months therapy, four died acute neurotoxoplasmosis 31 showed improvement. Of 24 evaluable for long-term 14 (58 percent) achieved complete resolution 10 late (n = 7) and/or 6) sequelae. Six experienced relapses, which occurred within weeks treatment discontinuation in seven 10. Reintroduction led to relapse eight cases. These results correlated brain anatomic 15 autopsied Side effects, noted 25 35, mainly hematologic toxicity 21) cutaneous rash 12). However, be definitively stopped only cases sulfadiazine alone withdrawn other data suggest that pyrimethamine/sulfadiazine is highly efficacious life-long needed prevent relapses AIDS.