Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance.

摘要: Athletic performance is influenced by a complex interplay among the environment and suite of genes, which contributes to system-wide structure function. In panel elite non-elite Thoroughbred horses (n=148), we genotyped 68 SNPs in 17 putative exercise-relevant genes chosen from genome scan for selection. We performed series case-control quantitative association tests relationships with racecourse performance. Thirteen nine were significantly (P<0.05) associated phenotype. selected five four (ACSS1, ACN9, COX4I1, PDK4) validation an independent sample set Thoroughbreds (n=130). Two PDK4 gene validated (P<0.01) associations racing When all samples considered together (n=278), PDK4_ 38973231 SNP was strongly (P<0.0005) Individuals A:A A:G genotypes had 16.2-16.6 lb advantage over G:G individuals terms handicap rating. Re-sequencing further genotyping will be required identify causative variant that likely influencing exercise-induced variation expression gene. Notwithstanding, this information may employed as marker selection racehorses genetic potential superior ability.