pharmacotherapy Update: Risperidone in the Treatment of schizophrenia

摘要: The paper is a review of the clinical use risperidone, an antipsychotic introduced in treatment schizophrenia 1994. Randomized controlled trials, naturalistic studies and extensive experience have definitively shown strong efficacy effectiveness risperidone other psychotic disorders. On basis available evidence, no drug has superior disorders, with significant exception clozapine. wide last 15 years confirmed favorable safety index. Some features render it uniquely useful management including very range dosage, availability liquid long-term injectable forms. Finally, currently generic form, at lower cost. However, presents major limitations. A substantial number patients symptoms do not respond to whatever its dose. Most these will need For some treated patients, extrapyramidal side effects remain serious concern. Weight gain, metabolic syndrome, hyperprolactinemia related are frequent may be severe, unacceptable, even dangerous patients.