Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters
作者： J H Lee , H J Rim , U B Bak
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摘要: The study was carried out to observe the effects of Clonorchis sinensis Infection on induction cholangiocarcinoma in Syrian golden hamsters which 15 ppm dimethylnitrosamine (DMN) solution administered for 8 weeks. histopathological changes bile duct and liver cells were observed at 11th week. In six (75%) treated with DMN then infected C. sinenis, livers developed 10 weeks after infestation sinenis. features lesions adenomatous or papillary hyperplasia epithelia showing distinct anaplastic mucinous cell metaplasia necrotic area. received either sinenis alone, showed only hyperplastic epithelial cells. It suggested that infection administration could be a synergism development hamsters. Key words: sinensis, cholangiocarcinoma, hamster, dinethylnltrosamine.
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