Celiac disease and autoimmune endocrinologic disorders.

摘要: Patients with insulin-dependent diabetes mellitus, autoimmune thyroid disease, Addison's and alopecia areata are at increased risk of celiac disease. We investigated whether patients more than one endocrinologic disorder even susceptible to disease or have celiac-type mucosal inflammation. All 62 found such multiple diseases in 1994-1996 were investigated. Small bowel biopsy was performed on all voluntary nonceliac subjects. The villous structure density intraepithelial lymphocytes examined, HLA-DQ alleles determined. Seven (11%) had disease: six cases detected earlier there new case; addition, two minor deterioration five an gammadelta+ T-cells. HLA-DQ2 DQ8 subjects changes. disorders clearly run developing some them changes compatible the early signs