Understanding the mechanism of drug delivery from thickened fluids to aid swallowing of medications
作者： Yady Juliana Manrique Torres
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摘要: Abstract Medications are often crushed and mixed with foods or fluids to aid drug delivery for those who cannot prefer not swallow whole tablets capsules. Dysphagic patients have the added problem of being unable safely fluids, so thickeners ensure safe swallowing. These thickened then also used deliver medications in replacement water. This thesis explores influence water co-administration on release gastric fluid, effect rheological properties these agents their contribution describing mechanism release. The literature review (Chapter 1) examines oral dosage form administration, as a means medication mechanisms It is highlighted that potential alter but prediction currently reported. Chapter 2 investigates an indicator compromise bioavailability.
uq.edu.au参考文章(149)
Simon B. Ross-Murphy, Victor J. Morris, Edwin R. Morris, Molecular viscoelasticity of xanthan polysaccharide Faraday Symposia of The Chemical Society. ,vol. 18, pp. 115- 129 ,(1983) , 10.1039/FS9831800115
L. Kalantzi, C. Reppas, J.B. Dressman, G.L. Amidon, H.E. Junginger, K.K. Midha, V.P. Shah, S.A. Stavchansky, Dirk M. Barends, Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol) Journal of Pharmaceutical Sciences. ,vol. 95, pp. 4- 14 ,(2006) , 10.1002/JPS.20477
Jill E Senner, Jerilyn Logemann, Steven Zecker, Deborah Gaebler-Spira, Drooling, Saliva Production, and Swallowing in Cerebral Palsy Developmental Medicine & Child Neurology. ,vol. 46, pp. 801- 806 ,(2004) , 10.1017/S0012162204001409
H. Vogelpoel, J. Welink, G.L. Amidon, H.E. Junginger, K.K. Midha, H. Möller, M. Olling, V.P. Shah, D.M. Barends, Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol. Journal of Pharmaceutical Sciences. ,vol. 93, pp. 1945- 1956 ,(2004) , 10.1002/JPS.20131
Venkata Reddy M, Sadanandam M, Vijayanand P, Kulkarni Pk, Formulation, Development and Evaluation of Novel Dosage Form Containing Silk Fibroin for Elderly Patients ,(2012)
John D. Cleary, Pamela C. Evans, Ahmed H. Hikal, Stanley W. Chapman, Administration of crushed extended-release pentoxifylline tablets: bioavailability and adverse effects American Journal of Health-system Pharmacy. ,vol. 56, pp. 1529- 1534 ,(1999) , 10.1093/AJHP/56.15.1529
Wylie J. Dodds, The physiology of swallowing Dysphagia. ,vol. 3, pp. 171- 178 ,(1989) , 10.1007/BF02407219
Richard Griffith, Tablet crushing and the law The Pharmaceutical Journal. ,vol. 271, pp. 90- 91 ,(2003)
M. K. Kottke, S. E. Rosenbaum, C. T. Rhodes, G. Stetsko, Problems encountered by the elderly in the use of conventional dosage forms Journal of Geriatric Drug Therapy. ,vol. 5, pp. 77- 92 ,(1990)
Dennis J Cordato, Daniel K Y Chan, Gregory N White, Bin S Ong, Fintan O'Rourke, Dysphagia: causes, assessment, treatment, and management. Geriatrics. ,vol. 63, pp. 15- 20 ,(2008)