A red fluorescent probe for ribonucleic acid (RNA) detection, cancer cell tracing and tumor growth monitoring
作者： Lei Wang , Qi Xia , Ruiyuan Liu , Jinqing Qu
DOI: 10.1016/J.SNB.2018.07.018
关键词:
摘要: Abstract A red fluorescent probe, PFB, is designed and synthesized, which presents several remarkable features including a large Stokes shift (85 nm), long emission wavelength, high photostability good biocompatibility. PFB also displays the solvent-dependent effect, verified by density functional theory (DFT) calculations. Additionally, can act as probe for cellular imaging with uptake efficiency highly sensitive detection toward RNA under low optimum concentration (1 μM), enables it to achieve cancer cell tracing in vitro tumor growth monitoring vivo. The results of real-time tracking experiment reveal that be traced stained HepG-2 cells 11 generations monitor 18 days. This work highlights potential application promising alternative commercial probes.
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