摘要: Background: Intestinal drug metabolism and transport are now well recognized determinants of disposition in humans. During the last decade, various animal models lacking transporters have been generated order to investigate role for absorption, distribution elimination. Objective: In this review use investigation intestinal will be discussed. Methods: Publications describing knockout animals (e.g., P-glycoprotein, Bcrp, Oct1) regarding characterized by mutations genes Mrp2) were mainly considered review. Results/conclusion: Knockout mouse ABC highly valuable tools efflux bioavailability compounds.
informahealthcare.com参考文章(99)
Jörg König, Anne T. Nies, Yunhai Cui, Inka Leier, Dietrich Keppler, Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochimica et Biophysica Acta. ,vol. 1461, pp. 377- 394 ,(1999) , 10.1016/S0005-2736(99)00169-8
A H Schinkel, E Wagenaar, C A Mol, L van Deemter, P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. Journal of Clinical Investigation. ,vol. 97, pp. 2517- 2524 ,(1996) , 10.1172/JCI118699
Yasuhisa Adachi, Hiroshi Suzuki, Alfred H. Schinkel, Yuichi Sugiyama, Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen Molecular Pharmacology. ,vol. 67, pp. 923- 928 ,(2005) , 10.1124/MOL.104.007393
Hermann Koepsell, Katrin Lips, Christopher Volk, Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharmaceutical Research. ,vol. 24, pp. 1227- 1251 ,(2007) , 10.1007/S11095-007-9254-Z
R.L. Juliano, V. Ling, A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 455, pp. 152- 162 ,(1976) , 10.1016/0005-2736(76)90160-7
Martin F. Fromm, Importance of P-glycoprotein at blood-tissue barriers. Trends in Pharmacological Sciences. ,vol. 25, pp. 423- 429 ,(2004) , 10.1016/J.TIPS.2004.06.002
Friederike Meyer-Wentrup, Ullrich Karbach, Valentin Gorboulev, Petra Arndt, Hermann Koepsell, Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. Biochemical and Biophysical Research Communications. ,vol. 248, pp. 673- 678 ,(1998) , 10.1006/BBRC.1998.9034
Dirk Gründemann, Valentin Gorboulev, Stepan Gambaryan, Maike Veyhl, Hermann Koepsell, Drug excretion mediated by a new prototype of polyspecific transporter Nature. ,vol. 372, pp. 549- 552 ,(1994) , 10.1038/372549A0
Gabor Kottra, Hannelore Daniel, The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology Pflügers Archiv: European Journal of Physiology. ,vol. 447, pp. 610- 618 ,(2004) , 10.1007/S00424-003-1101-4
Hiroyuki Tsujii, Jörg König, Daniel Rost, Birgit Stöckel, Ulrich Leuschner, Dietrich Keppler, Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin–Johnson syndrome Gastroenterology. ,vol. 117, pp. 653- 660 ,(1999) , 10.1016/S0016-5085(99)70459-2