Non-Alcoholic Fatty Liver Disease (NAFLD): The Lipid Disease of the Liver and the Effect of Statins

摘要: Non-alcoholic fatty liver disease (NAFLD) is currently the most common disease. steatohepatitis (NASH) advanced form of NAFLD to which a subpopulation patients progress. While manifested by hepatic steatosis, NASH has additional features inflammation, cell injury and ballooning, mitochondrial changes and/or fibrosis. The understanding pathogenesis been evolving but still not complete. Fat accumulation in first step process. It occurs when there increased caloric intake de novo lipogenesis. Peroxisome proliferator-activated receptors (PPARs), Farnesoid X receptor (FXR) (LXR) have shown play role pathogenesis. Many mechanisms are known be involved progress NASH, including oxidative stress, endotoxins, cytokines, dysfunction induction cytochrome P450 system. More recently discovered possible include gut microbiota, dietary fructose, toll-like (TLRs), nucleotide-binding oligomerization domain (NOD-like receptors), hedgehog signaling pathway.