Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

摘要: Purpose Targeted therapy with the humanized monoclonal antibody trastuzumab has become a mainstay for human epidermal growth factor receptor 2 (HER2) –positive breast cancer (BC). The mechanisms of action have not been fully elucidated, and data available to date are reviewed here. impact on clinical benefit also is discussed. Methods An extensive literature review proposed was performed. Results At least five potential extracellular intracellular antitumor identified in preclinical setting. These include activation antibody-dependent cellular cytotoxicity, inhibition domain cleavage, abrogation signaling, reduction angiogenesis, decreased DNA repair. effects lead tumor cell stasis and/or death. Clinical from trastuzumab-based both early advanced BC demonstrated. use...